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Opened Oct 30, 2025 by Arron Gavin@arrongavin0212
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Take Danger, Suppose Large

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This household accommodates only one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was found to methylate, moreover histone, quite a few non-histone proteins, including p53, solicitor news DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and components of the TATA binding protein (TBP) complex, TBP-associated elements TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-Ok (target lysine is bold), can also be recognized by the H3K4 demethylase KDM1A/LSD1, which is able to eradicating the methyl mark on most of these substrates 17 , 94 Due to this fact KMT7/KDM1A has emerged as a traditional model for dynamic lysine methylation of each histone and non-histone proteins.

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Reference: arrongavin0212/6139122#2