In contrast with mouse thymocytes, mouse ES cells include greater ranges of complete genomic H3K4me3 and have larger H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 46 In agreement with this, international decreases in H3K4me3 ranges occur during retinoic acid (RA)-induced differentiation of mouse ES cells forty seven In addition, there are dynamic changes in H3K4me3 profiles at specific units of genes throughout ES cell differentiation.

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This family contains just one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was discovered to methylate, besides histone, solicitor news quite a few non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor solicitor law firms kappaB (NFκB), and parts of the TATA binding protein (TBP) complicated, TBP-related factors TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Okay/R-S/T-Okay (goal lysine is bold), is also recognized by the H3K4 demethylase KDM1A/LSD1, which is able to eradicating the methyl mark on most of those substrates 17 , 94 Due to this fact KMT7/KDM1A has emerged as a classic model for dynamic lysine methylation of both histone and non-histone proteins.

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